Kyler Murray has been labeled as ‘questionable’ for Sunday’s game and that could make him a game-time decision.
Lamar Jackson will not start against the Rams and the team will go with Cooper Rush once again.
Mac Jones is listed as questionable for the 49ers game with knee and oblique injuries.
As the NFL season approaches the one-third mark, injuries have piled up. At this point, if your favorite team’s quarterback isn’t on the weekly injury report, consider yourself lucky.
Week 6 features just one divisional matchup – AFC North foes Cleveland and Pittsburgh facing off – but plenty of games between teams with playoff aspirations. Having your starting quarterback available is huge for these matchups.
Cincinnati made a change leading up to Week 6 by trading in-division for the Browns’ former starter, Joe Flacco. He’ll suit up for his first start for the Bengals Sunday against the Green Bay Packers.
The Bengals made that move to stay in contention while franchise quarterback Joe Burrow heals up from toe surgery.
They’re not the only team potentially missing their starter this week, though. Here’s the latest on quarterbacks across the league for Week 6.
Kyler Murray injury update
Arizona has a tough road game this week in Indianapolis against the 4-1 Colts. The Cardinals are 2-3 and need a win to keep pace in an NFC West that’s far more competitive in 2025.
That makes Murray’s health crucial for their Week 6 tilt. Murray injured his foot during the team’s Week 5 loss to the Tennessee Titans and did not practice on Wednesday or Thursday. He was limited on Friday.
He’s been labeled as ‘questionable’ for Sunday’s game and that could make him a game-time decision.
Arizona moved quarterback Kedon Slovis from the practice squad to the active roster, per reports. That shows the team is preparing to operate without Murray in Week 6 as Slovis would back up veteran Jacoby Brissett.
Lamar Jackson injury update
Jackson left the Ravens’ Week 4 loss to the Kansas City Chiefs with a hamstring injury that’s kept him sidelined ever since. Baltimore started veteran Cooper Rush against the Houston Texans in Week 5 and lost 44-10 at home.
This week the team plays the Los Angeles Rams at home again before their bye week. Jackson will not start against the Rams and the team will go with Rush once again.
Brock Purdy injury update
Purdy suffered toe and shoulder injuries in Week 1 against the Seattle Seahawks. He made a return to the starting lineup in Week 4 against the Jacksonville Jaguars and did not look fully healthy as the team lost its first game of the season.
He missed Week 5 against the Rams and it’ll be the same case in Week 6 against Tampa Bay. The 49ers’ franchise quarterback will continue to recover from his toe injury.
San Francisco is on the road for three of their next four games. Purdy still has not been put on injured reserve, which is promising for his return. If he were put on IR, he’d have to miss at least four weeks.
Mac Jones injury update
Purdy’s backup is also dealing with injuries this week. He had a career game on ‘Thursday Night Football’ in Week 5 to lead the 49ers to a win over the Rams and stay undefeated as a starter in 2025 at 3-0.
With Purdy out for the game, Jones would be the primary starter in Week 6 against the Buccaneers. But he’s listed as questionable for the game with knee and oblique injuries.
Jones practiced all week but was limited in each session. That was the same in Week 4 when he missed the 49ers’ game against the Jaguars.
San Francisco has elevated former United Football League MVP Adrian Martinez from the practice squad for the game. If Jones can’t play, Martinez will make his first NFL start against Todd Bowles and the Buccaneers.
