Lions-Chiefs could be the sexiest matchup of Week 6 and has a prime-time stage.
But Jags-Seahawks or 49ers-Bucs could actually prove the most highly competitive contests.
Two more teams will be on their byes for Week 6.
Week 6 of the NFL’s 2025 regular-season schedule kicks off Thursday night, the heated NFC East rivalry between the Philadelphia Eagles and New York Giants resuming with both clubs trying to get back into the win column following defeats last weekend.
The league’s International Series resumes Sunday morning in London, former U.K. ambassador Woody Johnson’s winless New York Jets technically hosting the suddenly surging Denver Broncos at Tottenham Hotspur Stadium. That will launch a fairly pedestrian lineup of Sunday games – Seahawks-Jaguars and 49ers-Buccaneers appearing to be the best of the bunch.
“Sunday Night Football” will feature what once looked like – and still could be – a Super Bowl 60 preview as the scalding Detroit Lions, winners of four in a row, visit the floundering but perpetually dangerous Kansas City Chiefs.
The docket concludes with yet another Monday night doubleheader, Bills-Falcons and Bears-Commanders putting the finishing touches on this week’s menu.
(The Houston Texans and Minnesota Vikings will be off as the second round of byes kick in.)
How does it all unfold? USA TODAY Sports’ panel of NFL experts serve up their weekly selections and scores:
(Odds provided by BetMGM)
NFL Week 6 picks, predictions and odds
Philadelphia Eagles at New York Giants
Denver Broncos at New York Jets
Dallas Cowboys at Carolina Panthers
Los Angeles Chargers at Miami Dolphins
Seattle Seahawks at Jacksonville Jaguars
Cleveland Browns at Pittsburgh Steelers
Los Angeles Rams at Baltimore Ravens
Arizona Cardinals at Indianapolis Colts
New England Patriots at New Orleans Saints
Tennessee Titans at Las Vegas Raiders
San Francisco 49ers at Tampa Bay Buccaneers
Cincinnati Bengals at Green Bay Packers
Detroit Lions at Kansas City Chiefs
Buffalo Bills at Atlanta Falcons
Chicago Bears at Washington Commanders
