The San Francisco 49ers have had more than their fair share of injuries to star players through two weeks of the season. And yet, they may be facing one more.
Edge rusher Nick Bosa exited Sunday’s Week 3 game against the Arizona Cardinals during the second quarter and has been ruled out for the remainder of the game with a knee injury. As he returned to the locker room with trainers, the five-time Pro Bowler gestured to fans in the stands with a thumbs down.
Bosa entered Sunday’s divisional clash with two sacks through two games – one in each of his first two games. An injury to the edge rusher would mark a fourth injured star player for the 49ers already this season, following tight end George Kittle (hamstring), quarterback Brock Purdy (toe) and wide receiver Jauan Jennings (ankle/shoulder).
Nick Bosa injury update
Bosa exited the 49ers’ Week 3 matchup with the Cardinals during the second quarter on Sunday. After a brief period in San Francisco’s blue medical tent on the sideline, the edge rusher returned to the locker room with a couple of trainers. He gestured a thumbs down to fans in the stands on his way off the field.
The 49ers have ruled their star defender out with a knee injury.
49ers DE depth chart
Nick Bosa
Mykel Williams
Sam Okuayinonu
Yetur Gross-Matos
Bryce Huff
Bosa is the leader of San Francisco’s pass-rush attack and still leads the team with his two sacks through two weeks. Williams is the other most notable player on the 49ers’ depth chart at defensive end as the 49ers’ first-round pick in the 2025 NFL Draft.
This story will be updated as more information becomes available.
