Christian McCaffrey was listed as questionable for the 49ers’ Week 1 game against the Seahawks.
The running back’s practice participation decreased throughout the week due to a calf injury.
The star running back had an interesting week of practice, to say the least. After being a full participant on Wednesday, he was limited on Thursday and missed practice entirely on Friday.
McCaffrey spent time on the shelf in 2024 as he nursed an Achilles injury, and unfortunately, his 2025 season is off to similar start.
That all paints a murky picture for his availability on Sunday in San Francisco’s 2025 debut vs. divisional rival Seattle.
Here’s the latest on McCaffrey, his calf injury and his status ahead of Sunday’s matchup:
Is Christian McCaffrey playing today?
The 49ers running back was a ‘big part’ of Saturday’s walkthrough, potentially signaling that he could play on Sunday.
McCaffrey is officially listed as ‘questionable’ ahead of the San Francisco 49ers’ matchup vs. the Seattle Seahawks. NFL Network reported Saturday that McCaffrey is likely to play.
McCaffrey told reporters Friday that he feels ‘great’ and that he plans to play. He also acknowledged his lengthy injury history and how that played into the abundance of caution in holding him out of practice on Friday.
The running back is, unfortunately, no stranger to injury reports and IR stints. He spent time on the sidelines in 2025 while he dealt with Achilles tendinitis and a PCL injury, ultimately playing in just four games last season.
This story will be updated.
